Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma

Figure 1 Pea3 expression in normal-adenoma-carcinoma (colon) and human colorectal carcinoma cell lines. A: Box plot of Pea3 transcript expression in normal colon tissue, adenoma, and adenocarcinoma samples. Oncomine™ compendium was utilized for analysis (Skrzypczak 2 colon sample set). Expression is shown as log₂ transformation of median-centered intensity. Black line represents the median; blue box, 25/75 percentile; bars, 10/90 percentile; dots, minimum and maximum values; B: Western blot analysis of Pea3 expression in human colorectal cancer cell lines. Shown are blots for Pea3 and β-actin loading control. Representative of three independent experiments.