Helicobacter pylori infection and atopic diseases: Is there a relationship? A systematic review and meta-analysis

Table 1 Summary of studies evaluating the prevalence of Helicobacter pylori infection in atopic/allergic (cases) and non-atopic/non-allergic subjects (controls) n (%)

Ref.	Location	Population	H. pylori measure	Definition of atopy/allergic disease	H. pylori +/atopic-allergic	H. pylori +/non atopic-non allergic
Figura et al[15]	Italy	Adult	Anti-H. pylori IgG	Specific IgE to alimentary antigens	16 (42.1)	26 (48.3)
Figura et al[15]	Italy	Adult	Anti-H. pylori CagA IgG	Specific IgE to alimentary antigens	24 (65.5)	15 (28.0)
Matricardi et al[16]	Italy	Adult	Anti-H. pylori IgG	Positive skin prick test, total IgE and specific IgE	35 (15.0)	44 (18.0)
Bodner et al[17]	Scotland	Adult	Anti-H. pylori IgG	Questionnaires (about any occurrence of wheezing or whistling in the chest)	49 (57.6)	93 (48.9)
Bodner et al[17]	Scotland	Adult	Anti-H. pylori IgG	Skin reactivity, total IgE and specific IgE	77 (51.3)	65 (52.0)
Tsang et al[18]	China	Adult	Anti-H. pylori IgG	Symptoms of asthma twice a week, FEV1 of 80% of predicted value or >, reversibility of greater than 15% with salbutamol, PC20 of less than 8 mg/mL histamine	43 (47.3)	37 (38.1)
Radon et al[19]	Germany	Adult	Anti-H. pylori IgG	Questionnaires (about any occurrence of allergic symptoms) and specific IgE	18 (19.8)	50 (21.7)
Jun et al[20]	Japan	Adult	Anti-H. pylori IgG	Symptoms of asthma twice a week, FEV1 of 80% of predicted value or >, reversibility of greater than 15% with salbutamol, PC20 of less than 8 mg/mL histamine	27 (58.7)	26 (54.2)
Jun et al[20]	Japan	Adult	Anti-H. pylori CagA IgG	Symptoms of asthma twice a week, FEV1 of 80% of predicted value or >, reversibility of greater than 15% with salbutamol, PC20 of less than 8 mg/mL histamine	10 (21.7)	9 (18.8)
Janson et al[21]	Iceland, Sweden, Estonia	Adult	Anti-H. pylori IgG	Specific IgE to inhalant allergens	81 (24.8)	337 (36.6)
Shiotani et al[22]	Japan	Adult	Anti-H. pylori IgG	Questionnaires and direct interviews	42 (11.4)	72 (17.6)
Konturek et al[23]	Germany	Adult	C13-urea breath test and anti- H. pylori CagA IgG	Clinical history, specific IgE, skin prick test, food challenge	14 (33.3)	8 (40.0)
Reibman et al[24]	Unites States	Adult	Anti H-pylori IgG and anti CagA IgG	Questionnaires (about any occurrence of asthma)	79 (24.8)	65 (31.3)
Holster et al[25]	Germany	Children	Anti-H. pylori IgG anti-H pylori CagA IgG	Questionnaires (about any occurrence of wheezing)	12 (5.9)	37 (10.9)
Holster et al[25]	Germany	Children	Anti-H. pylori IgG anti-H. pylori CagA IgG	Questionnaires (about any occurrence of allergic rhinitis)	25 (8.5)	24 (9.5)
Holster et al[25]	Germany	Children	Anti-H. pylori IgG anti-H pylori CagA IgG	Questionnaires (about any occurrence of atopic dermatitis)	21 (8.7)	28 (9.2)
Holster et al[25]	Germany	Children	Anti-H. pylori IgG anti-H. pylori CagA IgG	Questionnaires (about any physician diagnosis of asthma)	7 (7.1)	42 (9.4)

H. pylori: Helicobacter pylori.