Cytokine production in patients with cirrhosis and TLR4 polymorphisms

doi:10.3748/wjg.v20.i46.17516

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 14, 2014; 20(46): 17516-17524
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17516

Table 5 Spontaneous and stimulated cytokine production by peripheral blood cells in patients with cirrhosis not treated with norfloxacin

	Polymorphisms (n = 4)	Wild-type (n = 6)	P value
Spontaneous TNF-α (pg/mL)	464.3 (223.6-3920.1)	813.1 (591-1573)	0.25
TNF-α after LPS (pg/mL)	3166 (931.8-5078)	2936 (1272-4547)	0.76
TNF-α after LTA (pg/mL)	2766 (2291-4798)	1927 (241.3-4455)	0.17
Spontaneous IL-6 (pg/mL)	699.4 (320.8-1145.6)	5540 (1538-26053.9)	< 0.001
IL-6 after LPS (pg/mL)	27880 (19100-30070)	29000 (24960-32670)	0.47
IL-6 after LTA (pg/mL)	29660 (27970-30290)	29860 (3269-32170)	1.00
Spontaneous IL-10 (pg/mL)	13.2 (6.5-39.1)	135.6 (36.2-318.1)	0.02
IL-10 after LPS (pg/mL)	949.5 (655-1474)	1467 (334.5-2100)	0.35
IL-10 after LTA (pg/mL)	606.8 (376-1234)	897.6 (86.66-1530)	0.91

TNF-α: Tumour necrosis factor-alpha; LPS: Lipopolysaccharide; LTA: Lipoteichoic acid; IL: Interleukin.

Citation: Nieto JC, Sánchez E, Román E, Vidal S, Oliva L, Guarner-Argente C, Poca M, Torras X, Juárez C, Guarner C, Soriano G. Cytokine production in patients with cirrhosis and TLR4 polymorphisms. World J Gastroenterol 2014; 20(46): 17516-17524
URL: https://www.wjgnet.com/1007-9327/full/v20/i46/17516.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i46.17516