Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan

Table 3 Associations between diabetes-associated single-nucleotide polymorphisms and pancreatic cancer risk

Gene	SNP	Genotype	Case, n	Control, n	Age- and sex-adjusted OR (95%CI)	1Multivariable-adjusted OR (95%CI)
PPARG2	rs1801282	GG + CG	26	27	1.00	1.00
		CC	334	373	0.83 (0.47-1.46)	0.77 (0.43-1.38)
ADIPOQ	rs1501299	AA	19	38	1.00	1.00
		AC	155	167	1.79 (0.98-3.25)	1.71 (0.93-3.15)
		CC	186	195	1.86 (1.03-3.38)	1.85 (1.01-3.39)
CDKAL1	rs2206734	GG	114	138	1.00	1.00
		AG	184	195	1.15 (0.83-1.59)	1.18 (0.85-1.64)
		AA	62	67	1.16 (0.75-1.79)	1.21 (0.78-1.89)
ADRB3	rs4994	TT	228	255	1.00	1.00
		CT	114	131	0.92 (0.67-1.25)	0.88 (0.64-1.21)
		CC	18	14	1.37 (0.66-2.83)	1.36 (0.65-2.87)
KCNQ1	rs2237895	AA	153	156	1.00	1.00
		AC	175	193	0.95 (0.70-1.29)	0.92 (0.67-1.26)
		CC	32	51	0.62 (0.37-1.02)	0.62 (0.37-1.04)
KCNJ11	rs5219	CC	150	159	1.00	1.00
		CT	157	192	0.87(0.64-1.18)	0.90 (0.66-1.24)
		TT	53	49	1.14 (0.72-1.79)	1.19 (0.75-1.90)
TCF7L2	rs7903146	CC	354	394	1.00	1.00
		CT + TT	6	6	1.20 (0.38-3.83)	1.16 (0.36-3.72)

¹Adjusted for age, sex, body mass index, and cigarette smoking.