Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure

Table 2 Effect of amino acid L-arginine on liver function parameters in rats with acute hepatic failure

Gr. (n)	Bils, mg/dL	ASTs, IU/L	ALTs, IU/L	Albumins, mg/dL	Ammons,μmol/L
1 (8)
Sham	0.40 ± 0.26	252.50 ± 149.8	56.2 ± 9.9	2.9 ± 0.1	52.8 ± 38.1
2 (8)
Ga1N	3.43 ± 1.35	1624.12 ± 692.92	2098.6 ± 886.1	2.6 ± 0.1	275.7 ± 73.7
8 (8)
Sham L-ARG	0.38 ± 0.21	126.37 ± 33.95	53.75 ± 7.37	2.67 ± 0.09	50.7 ± 46.2
9 (8)
L-ARG/Ga1N	2.96 ± 0.67	1484.87 ± 328.75	1546.37 ± 349.75	2.75 ± 0.1	199.12 ± 42.8
10 (8)
2xL-ARG/Ga1N	2.92 ± 0.89	1611.75 ± 334.58	1603.75 ± 364.47	2.73 ± 0.06	193.87 ± 50.49
11 (8)
Ga1N/L-ARG	2.86 ± 0.94	1491.87 ± 421.49	1486.25 ± 450.83	2.42 ± 0.21	195.25 ± 41.69
12 (8)
Ga1N/2xL-ARG	2.96 ± 0.98	1446.25 ± 219.35	1435.62 ± 281.33	2.72 ± 0.11	180.5 ± 45.80
gr. 2 vs gr. 1	P < 0.004	P < 0.0001	P < 0.001	P < 0.001	P < 0.005
gr. 8 vs gr. 1	P < 0.11	P < 0.047	P < 0.60	P < 0.0007	P < 0.340
gr. 9 vs gr. 2	P < 0.41	P < 0.63	P < 0.14	P < 0.09	P < 0.032
gr. 10 vs gr. 2	P < 0.41	P < 0.96	P < 0.19	P < 0.10	P < 0.029
gr. 11 vs gr. 2	P < 0.37	P < 0.67	P < 0.12	P < 0.06	P < 0.024
gr. 12 vs gr. 2	P < 0.46	P < 0.52	P < 0.08	P < 0.20	P < 0.011

Biochemical parameters of the liver were evaluated 48 h after saline or Ga1N injection. Values are mean ± SE. Gr. 1: Sham; Gr. 2: Given 1.1 g/kg Ga1N; Gr. 8: Sham L-ARG group, given 150 mg/kg L-ARG; Gr. 9: Given 150 mg/kg L-ARG 48 h and 24 h before Ga1N; Gr. 10: Given 300 mg/kg L-ARG 48 h and 24 h before Ga1N; Gr. 11: Given 150 mg/kg L-ARG 24 and 48 h after Ga1N; Gr. 12: Given 300 mg/kg L-ARG 24 and 48 h before Ga1N. Bil_s: Serum bilirubin; AST_s: Serum aspartate aminotransferase; ALT_s: Serum alanine aminotransferase; Albumins: Serum albumin; Ammons: Serum ammonium.