Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure

Table 1 Effect of N-nitro-L-arginine methyl ester on liver function parameters in rats with acute hepatic failure

Gr. (n)	Bils, mg/dL	ASTs, IU/L	ALTs, IU/L	Albumins, g/dL	Ammons, μmol/L
1 (8)
Sham	0.40 ± 0.26	252.5 ± 149.8	56.2 ± 9.9	2.9 ± 0.1	52.8 ± 38.1
2 (8)
Ga1N	3.43 ± 1.35	1624.12 ± 692.92	2098.6 ± 886.1	2.6 ± 0.1	275.7 ± 73.7
3 (8)
Sham L-NAME	0.28 ± 0.17	221.37 ± 150.05	82.2 ± 16.2	2.98 ± 0.11	26.9 ± 7.8
4 (8)
L-NAME/Ga1N	3.27 ± 0.52	1309.25 ± 349.48	1343.75 ± 451.92	2.73 ± 0.14	210 ± 48.18
5 (8)
2xL-NAME/Ga1N	2.67 ± 075	1682.25 ± 433.24	1590.12 ± 504.26	2.68 ± 0.15	193.87 ± 80.92
6 (8)
Ga1N /L-NAME	2.58 ± 0.46	1424.87 ± 422.99	1425 ± 475.61	2.76 ± 0.15	206.37 ± 51.11
7 (8)
G Ga1N/2xL-NAME	3.1 ± 0.75	1691.12 ± 370.80	1707.12 ± 448.87	2.7 ± 0.17	201.5 ± 42.33
Gr. 2 vs Gr. 1	P < 0.004	P < 0.0001	P < 0.001	P < 0.001	P < 0.005
Gr. 3 vs Gr. 1	P < 0.37	P < 0.70	P < 0.031	P < 0.15	P < 0.089
Gr. 4 vs Gr. 2	P < 0.77	P < 0.30	P < 0.064	P < 0.17	P < 0.068
Gr. 5 vs Gr. 2	P < 0.21	P < 0.85	P < 0.064	P < 0.46	P < 0.067
Gr. 6 vs Gr. 2	P < 0.13	P < 0.52	P < 0.098	P < 0.12	P < 0.060
Gr. 7 vs Gr. 2	P < 0.57	P < 0.82	P < 0.31	P < 0.40	P < 0.036

¹The P value is significant. Biochemical parameters of the liver were evaluated 48 h after saline or Ga1N injection. Values are mean ± SE. Gr. 1: Sham; Gr. 2: Given 1.1 g/kg Ga1N; Gr. 3: Sham L-NAME, given 100 mg/kg L-NAME; Gr. 4: Given 100 mg/kg L-NAME 48 h and 24 and before Ga1N; Gr. 5: Given 200 mg/kg L-NAME 48 h and 24 h before Ga1N; Gr. 6: Given 100 mg/kg L-NAME 24 and 48 h after Ga1N; Gr. 7: Given 200 mg/kg L-NAME 24 and 48 h after Ga1N. Bils: Serum bilirubin; ASTs: Serum aspartate aminotransferase; ALTs: Serum alanine aminotransferase; Albumins: Serum albumin; Ammons: Serum ammonium.