Hematopoietic stem cell transplantation for non-malignant gastrointestinal diseases

Table 1 Indirect evidence for efficacy of hematopoietic stem cell transplantation in inflammatory bowel disease

Ref.	SCT	Original indication	No./type IBD	Conditioning	Results/remarks
Drakos et al[37]	Allo-SCT	NHL	1/fistulizing CD	BCNU/Etoposide, Cy, ara-C and Melphalan	Remission/6 mo follow up
Kashyap et al[40]	Auto-SCT	NHL	1/Perianal CD	Cy,VP16+TBI	Remission 7 yr/Crohn’s at age 13 yr ASCT at 20 yr
Lopez-Cubero et al[38]	Allo-SCT	Leukemia	5/CD	Cy/TBI	3 pts has lasting remission
Söderholm et al[41]	Auto-SCT	AML	1/Fistulizing CD	Cy/TBI	Remission 5 yr
Ditschkowski et al[39]	Auto-SCT	AML/CML/MDS	11/7 CD +4 UC	Various	Remission in 10/Follow up 34 mo
Anumakonda et al[42]	Auto-SCT	NHL	1/CD	CHOP	Remission 8 yr/Relapse after 8 yr

CD: Crohn’s disease; NHL: Non-Hodgkin’s disease; UC: Ulcerative colitis; Cy: Cyclophosphamide; AML: Acute myeloid leukemia; MDS: Myelodysplastic syndrome; CML: Chronic myeloid leukemia; TBI: Total body irradiation; CHOP: Cyclophosphamide Adriamycin Vincristine Prednisone.