Early-onset colorectal cancer: A separate subset of colorectal cancer

Table 3 Proportion of microsatellite instability in early-onset colorectal cancers series and their age of onset

Study	Age of CRC onset, yr	Population	MSI, n (%)
Losi et al[9]	≤ 45	Unselected CRC surgical patients	71 (19.7)
Liang et al[10]	≤ 40	Unselected CRC surgical patients	138 (40.5)
Perea et al[11]	≤ 45	Unselected CRC surgical patients	88 (13.6)
Jasperson et al[50]	< 36	Hereditary cancer registries	96 (29.1)
Durno et al[51]	< 25	Familial cancer registry	16 (72.7)
Farrington et al[52]	< 30	Cancer registries	50 (47.5)
Antelo et al[66]	< 50	Cancer registry	118 (22.9)

CRC: Colorectal cancer; MSI: Microsatellite instability.