Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma

Table 4 Preoperative factors associated with survival n (%)

Variable	Survival(n = 202)	Death(n = 96)	P value	Multivariate
				Relative risk	P value
Age (yr)	57.0 ± 9.6	55.2 ± 9.8	0.131
Gender (male)	150 (74.3)	82 (85.4)	0.102
Cause of HCC (HBV:HCV:Alcohol:Others)	143:14:9:36	70:4:7:15	0.568
PLT (× 103/μL)	151.84 ± 62.56	152.11 ± 84.19	0.975
Bilirubin (mg/dL)	1.24 ± 7.21	1.04 ± 1.15	0.783
ICG	12.05 ± 15.45	10.61 ± 9.21	0.496
CTP scores	5.31 ± 0.63	5.59 ± 0.84	0.003	1.682 (0.310-9.116)	0.066
MELD scores	6.08 ± 2.51	6.93 ± 3.76	0.020	5.413 (0.895-32.718)	0.547
AFP (ng/mL)	667.2 ± 3733.2	3086.7 ± 16970.2	0.057
> 100 (n = 101)	58 (28.7)	43 (44.8)	0.005	3.061 (1.183-7.922)	0.021
PIVKA II (mAU/mL)	399.6 ± 1200.3	941.6 ± 2169.4	0.066
> 100 (n = 55)	42 (20.8)	13 (13.5)	0.159
Tumor size (cm)	4.08 ± 2.86	5.30 ± 3.47	0.002
> 5 (n = 72)	36 (17.8)	36 (37.5)	< 0.001	1.796 (0.705-4.574)	0.220
Tumor number	1.17 ± 0.59	1.48 ± 1.19	0.005
multiple (n = 40)	20 (9.9)	20 (20.8)	0.010	2.475 (0.505-12.137)	0.264
SUVs on PET CT	4.09 ± 2.45	6.57 ± 4.35	0.001
> 3.5 (n = 47)	28 (13.9)	19 (19.8)	< 0.001	7.331 (2.182-24.630)	0.001
RER (n = 100)	0.75 ± 0.15	0.70 ± 0.13	0.295
< 0.6 (n = 11)	7 (3.5)	4 (4.2)	0.003

HCC: Hepatocellular carcinoma; HBV: Hepatitis B virus; HCV: Hepatitis C virus; PLT: Platelets; ICG: Indocyanine green; CTP: Child-Turcotte-Pugh; MELD: Model for End-stage Liver Disease; AFP: Alpha fetoprotein; PIVKA II: Protein induced by vitamin K absence or angiotensin-II; SUVs: Standardized uptake values; PET: Positron emission tomography; RER: Relative enhancement ratio.