Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea

Table 3 Comparison of clinical characteristics between familial and sporadic inflammatory bowel disease n (%)

	Familial CD (n = 17)	Sporadic CD (n = 51)	P value	Familial UC (n = 27)	Sporadic UC (n = 81)	P value
Disease activity (at diagnosis)	CDAI			Mayo score
Mean ± SD	120.5 ± 68.2	107.8 ± 82.1	0.207	3.6 ± 2.0	3.7 ± 1.8	0.673
< 150	11 (64.7)	36 (70.6)	0.761	0-2, 9 (33.3)	18 (22.2)	0.428
150 ≤ and < 220	4 (23.5)	8 (15.7)		3-5, 14 (51.9)	52 (64.2)
≥ 220	2 (11.8)	7 (13.7)		6-12, 4 (14.8)	11 (13.6)
No. of hospitalizations			0.175			0.794
0	9 (52.9)	35 (68.6)		25 (92.6)	73 (90.1)
1-2	6 (35.2)	14 (27.5)		1 (3.7)	7 (8.7)
≥ 3	2 (11.7)	2 (3.9)		1 (3.7)	1 (1.2)
No. of relapses			0.342			0.333
0	13 (76.5)	44 (86.3)		22	72
1-2	4 (23.5)	7 (13.7)		5	9
≥ 3	0 (0.0)	0 (0.0)		0	0
Relapse duration after diagnosis, mo	49.3 ± 65.5	38.9 ± 44.5	0.907	58.2 ± 102.2	21.3 ± 20.5	0.898
Follow-up duration after diagnosis, mo	84 (24-312)	36 (8-240)	0.008	96 (12-240)	60 (12-85)	0.170

Ulcerative colitis (UC) relapse was defined as a partial Mayo score ≥ 4 or surgery for disease aggravation[12]. Crohn’s disease (CD) relapse was defined as a Crohn’s disease activity index (CDAI) score ≥ 250, a CDAI score 150 ≤ CDAI score < 250 with a 75 point increase above the initial value during three consecutive weeks, or surgery for progressed Crohn’s disease, aside from perianal surgery[13].