Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea

Table 1 Demographic data of familial inflammatory bowel disease and sporadic inflammatory bowel disease

Phenotype	Familial CD (n = 17)	Sporadic CD (n = 51)	P value	Familial UC (n = 27)	Sporadic UC (n = 81)	P value
Sex			> 0.999			> 0.999
Male	14 (82.4)	42 (82.4)		15 (55.6)	45 (55.6)
Female	3 (17.6)	9 (17.6)		12 (44.4)	36 (44.4)
Age at diagnosis	28.2 ± 10.3	29.2 ± 10.5	0.742	36.2 ± 14.7	36.4 ± 12.8	0.951
≤ 16 yr (A1)	0 (0)	0 (0)	0.849	0 (0)	0 (0)	> 0.999
17-40 yr (A2)	14 (82.4)	43 (84.3)		13 (48.1)	39 (48.1)
> 40 yr (A3)	3 (17.6)	8 (15.7)		14 (51.9)	42 (51.9)
Age at symptom onset, yr	22.6 ± 9.5	23.5 ± 9.3	0.438	36.2 ± 14.5	36.7 ± 12.7	0.710
Main symptom at diagnosis
Abdominal pain	10 (58.8)	32 (62.7)	0.773	5 (18.5)	30 (37.0)	0.098
Diarrhea	5 (29.4)	16 (31.4)	0.880	11 (40.7)	22 (27.2)	0.232
Weight loss	0 (0.0)	2 (3.9)	> 0.999	0 (0.0)	0 (0.0)	> 0.999
Fever	0 (0.0)	1 (2.0)	> 0.999	0 (0.0)	0 (0.0)	> 0.999
Abdominal mass	0 (0.0)	0 (0.0)	> 0.999	0 (0.0)	0 (0.0)	> 0.999
Hematochezia	2 (11.8)	9 (17.6)	0.718	21 (77.8)	66 (81.5)	0.780
EIM	0	3		10	19
Somatitis	0 (0.0)	0 (0.0)	> 0.999	0 (0.0)	2 (2.5)	0.061
Arthritis and arthralgia	0 (0.0)	2 (4.2)	> 0.999	1 (3.7)	8 (9.9)	0.445
Erythema nodosum	0 (0.0)	1 (2.1)	> 0.999	4 (14.8)	5 (6.2)	0.223
Episcleritis	0 (0.0)	0 (0.0)	> 0.999	5 (18.5)	4 (4.9)	0.042

Data are presented as number (percentage) or mean ± SD. CD: Crohn’s disease; UC: Ulcerative colitis; EIM: Extraintestinal manifestation.