Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates

Table 1 Loci distribution of adefovir dipivoxil -resistant mutants n (%)

ADV-resistant mutants	Number of patients	prevalence of patients
rtA181T12 mutant/coexisting mutants3	40 (50.63)
rtV214A1 mutant/coexisting mutants	7 (8.86)
rtN236T1 mutant/coexisting mutants	5 (6.33)
rtP237H1 mutant	1 (1.27)
rtL180M4 + rtM204V456 + rtA181T12 coexisting mutants	4 (5.06)
rtL180M4 + rtT184L6 coexisting mutants, rtM204V45 + rtV207M/L/I4 + rtV214A1 mutant	1 (1.27)
rtL180M4 + rtM204V456 + rtS213T4 + rtA181T12 mutant	1 (1.27)
rtL180M4 + rtM204V456 + rtS213T4 + rtQ215S1 mutant, rtP237H1 coexisting mutants	1 (1.27)
rtL180M4 + rtM204V456 + rtQ215S1 + rtT184L6 mutant	1 (1.27)
rtL180M4 mutant, rtQ215S1 coexisting mutants	1 (1.27)
rtA181T12 + rtV214A1 coexisting mutants	1 (1.27)
rtA181T12 + rtN236T1 coexisting mutants	2 (2.53)
rtA181T1 mutant, rtN236T1 coexisting mutants	1 (1.27)
rtM204V45 + rtA181T12 coexisting mutants	1 (1.27)
rtM204V45 mutant, rtA181T12 coexisting mutants	1 (1.27)
rtM204V45 + rtV207M/L/I4 + rtQ215S1 mutant	1 (1.27)
rtM204V45 + rtV214A1 mutant	1 (1.27)
rtM204V45 mutant, rtA181T12 + rtQ215S1 coexisting mutants	1 (1.27)
rtM204V45 mutant, rtN238T1 coexisting mutants	1 (1.27)
rtV207M/L/I4 + rtA181T12 + rtV214A1 + rtN236T1 + rtM250L6 coexisting mutants	1 (1.27)
rtV207M/L/I4 + rtA181T12 + rtN236T1 coexisting mutants	1 (1.27)
rtV207M/L/I4 + rtV214A1 coexisting mutants	1 (1.27)
rtV207M/L/I4 + rtA181T12 + rtN236T1 coexisting mutants	1 (1.27)
rtS213T4 + rtA181T12 coexisting mutants	1 (1.27)
rtS213T4 + rtN236T1 + rtM250L6 mutant	1 (1.27)
rtN236T1 + rtN238T1 coexisting mutants	1 (1.27)

¹ADV-associated mutants: rtA181T, rtV214A, rtQ215S, rtN236T, rtP237H, rtN238T;

²Shared mutants of ADV, LAM, LdT: rtA181T[2];

³Coexisting mutants: wild strain and mutant strain coexistence;

⁴Lamivudine (LAM)-associated mutants: rtL180M, rtM204V, rtV207M/L/I, rtS213T;

⁵Telbivudine (LdT)-associated mutant: rtM204V;

⁶Entecavir (ETV)-associated mutants: rtT184L, rtM204V, rtM250L. ADV: Adefovir dipivoxil.