Efficacy and safety of herbal medicines in treating gastric ulcer: A review

Table 2 Efficacy and safety of herbal medicines for gastric ulcer in humans

Herbal extracts	No. of patients (M/F)	Treatment course (d)	Efficacy		Adverse effects	Ref.
			Herbal extract	Positive control
Rhizoma Coptidis, Radix Sanguisorbae, radix paeoniae alba, rhizoma bletilla, Chickens Gizzard membrane	60 (41/19)	42	Cure rate: 20% Effective rate: 85%	Cure rate: 10% Effective rate: 71.67%	None	[56]
Radix Astragali, Radix Aucklandiae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Chickens Gizzard membrane, radix notoginseng, radix paeoniae alba, Radix Scutellariae, Radix Glycyrrhizae	50 (35/25)	60	Cure rate: 72% Effective rate: 96%	N/D	Vomiting in one case	[57]
Radix Astragali, radix codonopsis, poria, Rhizoma Atractylodis Macrocephalae, dried orange peel, Radix Glycyrrhizae	841 (43/41)	60	Effective rate: 92.9%	N/D	N/D	[58]
Radix Bupleuri, Radix Codonopsis, radix paeoniae alba, rhizoma corydalis, rhizoma bletilla, margarita, indigo naturalis, radix glycyrrhizae	26 (15/11)	28	Effective rate 92.3%	Effective rate 92.3%	Temporary diarrhea at beginning	[60]
Margarita, borax, Rhizoma Coptidis, rhizoma bletilla, indigo naturalis, amber	90 (N/D)	30	Cure rate: 88.9% Effective rate: 96.7%	Cure rate: 82.8% Effective rate: 89.7%	None	[61]
Rhizoma curculiginis, Herba Epimedii, Radix Astragali, rhizoma bletilla, poria, Fructus Amomi, Radix Glycyrrhizae Preparata	622 (44/18)	30	Cure rate: 82.3% Effective rate: 98.4%	Cure rate: 81.4% Effective rate: 93.0%	5 cases had dry mouth; 7 cases had constipation	[62]
Radix Codonopsis, Herba Taraxaci, Radix Salviae miltiorrhizae, Rhizoma Atractylodes alba, Radix Glycyrrhizae	30 (22/8)	56	Cure rate: 50% Effective rate: 86.7%	Cure rate: 40% Effective rate: 70%	N/D	[63]
Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, Fructus Jujubae, Sacchaium Granorum, Radix Cynanchi Paniculati	80 (58/22)	28	Cure rate: 45% Effective rate: 93.75%	Cure rate: 10.26% Effective rate: 74.36%	N/D	[64]
Radix Astragali, Taraxacum mongolicum Hand, tokyo violet herb, Bulbus Lilii, Radix Linderae, Radix Salvia miltiorrhiza, radix paeoniae alba, Radix Glycyrrhizae	12 (ND)	28	Cure rate: 100%	Cure rate: 62.5%	N/D	[65]

¹Including gastritis;

²Including 41 cases of duodenal ulcer and 4 cases of gastric and duodenal ulcers. M: Male; F: Female; Cure: Clinical symptoms disappeared; Effective: Clinical symptoms improved; N/D: Not determined.