MicroRNAs in colorectal cancer: Role in metastasis and clinical perspectives

Table 4 MicroRNAs as diagnostic markers

MicroRNAs	Sensitivity	Specificity	Remarks	Ref.
	Plasma
miR-29a	69%	89.1%	Upregulated in CRC plasma, associated with advanced TNM stages	[82]
miR-92a	64%	70%	Upregulated in CRC plasma; could distinguish CRC from other GI cancers and IBD; not associated with TNM stages	[50]
miR-17-3p	89%	70%	Upregulated in CRC plasma	[51]
miR-92a	84%	71.2%	Upregulated in CRC plasma; not associated with TNM stages	[82]
	Fecal
miR-17-92 cluster	69.5%	81.5%	Upregulated in stool of CRC patients	[88]
miR-135	46.2%	95%	Upregulated in stool of CRC patients	[88]
miR-92a	50%	80%	Upregulated in stool of CRC patients	[89]
miR-21	50%	83%	Upregulated in stool of CRC patients	[89]

CRC: Colorectal cancer; miRNA: MicroRNA; TNM: Tumour-node-metastasis.