MicroRNAs in colorectal cancer: Role in metastasis and clinical perspectives

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Dec 7, 2014 (publication date) through Jan 4, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2014; 20(45): 17011-17019
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17011

Table 3 Intravasation, extravasation and colonization

MicroRNAs	Dysregulation	Effect	Ref.
	Intravasation and extravasation
miR-21	↓Pdcd4	↑ Intravasation and metastatic potential	[34,85]
miR-126	↓VCAM-1	↓ Decreased cell-cell adhesion, leukocytes-epithelial cell adherence, inflammation	[86]
miR-155		Required for adaptive and innate immunity	[40]
miR-17-92		Adaptive differentiation of B cells and conventional T cells	[40]
	Colonization
miR-328	↓ in SP cells	Low miR-328 expression correlated with high SP fraction	[79]
miR-26b	↓ HUES-17 and CRC cell line	↓ Cell growth and induction of apoptosis	[87]
miR-103/107	↓DAPK and KLF4	↑ Colonization	[69]

Citation: Muhammad S, Kaur K, Huang R, Zhang Q, Kaur P, Yazdani HO, Bilal MU, Zheng J, Zheng L, Wang XS. MicroRNAs in colorectal cancer: Role in metastasis and clinical perspectives. World J Gastroenterol 2014; 20(45): 17011-17019
URL: https://www.wjgnet.com/1007-9327/full/v20/i45/17011.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i45.17011