Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53

Figure 1 Estradiol and ER selective agonists impair cell proliferation in human LoVo cells. A: Structures of 17β-estradiol, propylpyrazole-triol (PPT), a selective agonist of ERα, and diarylpropionitrile (DPN), a selective agonist of ERβ; B: LoVo cells cultured in DMEM were treated with 17β-estradiol, PPT and DPN for 24 h and 48 h and were then analyzed for cell viability by the MTT assay. ^aP < 0.05 vs control; ^bP < 0.001 vs control (means ± SE, n = 3).