Causes and consequences of microsatellite instability in gastric carcinogenesis

Figure 1 Summary of microsatellite instability gastric cancer associated clinico-pathologic and molecular aspects. This figure summarizes the current knowledge on the molecular mechanisms underlying the acquisition of MSI in GC as well as the clinic, pathologic and molecular consequences of the MSI phenotype. MSI: Microsatellite instability; MMR: Mismatch repair; GC: Gastric cancer; H. pylori: Helicobacter pylori; 5-FU: 5-fluorouracil.