Laparoscopic vs open D2 gastrectomy for locally advanced gastric cancer: A meta-analysis

Table 2 Meta-analysis results of endpoints from all available studies

Measured outcome	Studies (n)	Patients (n)	OR, WMD, or HR	95%CI		P	Heterogeneity test		Pr >|z|
							I2	P
Operative outcomes
Operative time	13	2300	57.06	41.87	72.25	< 0.00001	90%	< 0.00001	0.502
Intraoperative blood loss	11	2064	-137.87	-164.41	-111.33	< 0.00001	90%	< 0.00001	0.533
PO outcomes
PO analgesic consumption	4	441	-1.94	-2.50	-1.38	< 0.00001	77%	0.005	0.308
Time to first ambulation	5	977	-1.03	-1.90	-0.16	0.02	97%	< 0.00001	1.000
Time to first flatus	9	1588	-0.98	-1.30	-0.66	< 0.00001	89%	< 0.00001	0.536
Time to first oral intake	6	987	-0.85	-1.67	-0.03	0.04	86%	< 0.00001	1.000
Length of PO hospital day	10	1782	-3.08	-4.38	-1.78	< 0.00001	88%	< 0.00001	0.721
Overall morbidity	13	2284	0.78	0.61	0.99	0.04	14%	0.30	0.161
Anastomotic stenosis	12	2108	0.89	0.36	2.16	0.79	0%	0.74	0.308
Anastomotic leakage	13	2284	0.74	0.36	1.50	0.40	0%	0.80	1.000
Duodenal stump leakage	13	2284	1.12	0.42	3.01	0.82	0%	0.83	1.000
Pancreatic fistula/ pancreatitis	13	2284	0.75	0.37	1.52	0.42	0%	0.91	0.308
Intra-abdominal bleeding	13	2284	0.99	0.41	2.38	0.98	0%	0.83	1.000
Ileus	12	2108	0.56	0.21	1.46	0.23	0%	0.73	1.000
Wound problems	13	2284	0.56	0.34	0.93	0.03	0%	0.66	0.152
Pneumonia	13	2284	0.38	0.21	0.71	0.002	17%	0.29	1.000
Reoperation	7	1289	1.58	0.58	4.31	0.37	0%	0.63	1.000
Mortality	13	2284	0.69	0.21	2.26	0.54	0%	0.64	-
Oncologic outcomes
Lymph nodes harvested (n)	13	2526	-0.11	-2.72	2.50	0.94	95%	< 0.00001	0.537
Tumor recurrence/metastasis	8	1587	0.79	0.60	1.04	0.09	20%	0.27	0.035
Local/lymphatic recurrence	5	853	0.79	0.46	1.34	0.38	0%	0.41	0.296
Peritoneal recurrence	5	853	1.20	0.70	2.07	0.50	0%	0.50	0.296
Distant metastasis	5	853	0.67	0.42	1.07	0.09	45%	0.12	0.089
Three-year DFS	4	703	1.02	0.64	1.61	0.94	0%	0.88	-
Three-year overall survival	8	1363	0.87	0.59	1.27	0.46	0%	0.99	-
Five-year DFS	3	652	1.02	0.66	1.57	0.92	0%	0.67	-
Five-year overall survival	3	652	0.79	0.46	1.34	0.38	0%	0.90	-

DFS: Disease-free survival; HR: Hazard ratio; OR: Odds ratio; PO: Postoperative; WMD: Weighted mean difference.