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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 28, 2014; 20(44): 16480-16488
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16480
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16480
Table 2 Studies of pulsed-wave high intensity focused ultrasound treatment for patients with advanced pancreatic cancer
Study | n | Patients | Treatment Method | HIFU Device | Outcome and Survival | Complications |
Wang et al[29] | 15 | Late-stage pancreatic cancer, unresectable, average tumor size 5.6 cm (2.2-8 cm) | Multiple-session HIFU monotherapy, average sessions 8.1 (2-12) | Pulsed HIFU irradiation, FEB-BY HIFU System | Pain relief: 13/13 (100%)No survival data available | Mild abdominal pain: 2/15 (13%) |
Li et al[30] | 25 | Advanced pancreatic cancer, unresectable, average tumor size unclear | One-session HIFU: 19 pts; 2-session HIFU: 6 pts; average sessions 1.2 | Pulsed HIFU irradiation, FEB-BY HIFU System | Performance statue and pain improvement: 23/25 (92%); median overall survival: 10 mo; 1-year survival: 42% | First-degree skin burn: 3/25 (12%) |
Ge et al[31] | 20 | A retrospective study for unresectable pancreatic cancer, average tumor size (4.5 ± 1.2) × (3.5 ± 1.0) cm | Multiple-session HIFU monotherapy; average HIFU session 9.3 ± 4.1 | Pulsed HIFU irradiation, FEB-BY HIFU System | Pain relief and survival data not reported | Mild abdominal pain: 5/25 (25%); subcutaneous fat callus: 4/25 (20%); 2nd-degree skin burn: 1/25 (5%); pancreatic effusion: 1/25 (5%) |
Xiong et al[32] | 89 | A retrospective study for unresectable pancreatic cancer. Tumor size not reported | Multiple-session HIFU monotherapy: 84 pts;HIFU + gemcitabine: 5 pts; HIFU sessions ranging 4-10 | Pulsed HIFU irradiation, FEB-BY HIFU System | Pain relief: 54/67(80%), median survival: 26.0 mo (stage II), 11.2 mo (stage III) and 5.4 mo (stage IV) | Superficial skin burns: 3/89 (3%); subcutaneous fat sclerosis: 8/89 (6%); asymptomatic pseudocyst: 1/89 (1%) |
Lee et al[33] | 12 | Advanced pancreatic cancer, unresectable, average tumor size 3.5 cm (2.3-5.3 cm) | Multiple-session HIFU monotherapy: 9 pts; HIFU + gemcitabine: 3 pts; average HIFU sessions: 4.2 (1-18) | Pulsed HIFU irradiation, FEB-BY HIFU System | Median survival for those receiving HIFU alone: 10.3 mo; Overall survival for 3 patients receiving the combined treatment: 26.0, 21.6 and 10.8 mo, respectively | Pancreatitis: 1/12 (8%); skin burn: 5/12 (41%); subcutaneous fat sclerosis: 2/12 (16%) |
- Citation: Wu F. High intensity focused ultrasound: A noninvasive therapy for locally advanced pancreatic cancer. World J Gastroenterol 2014; 20(44): 16480-16488
- URL: https://www.wjgnet.com/1007-9327/full/v20/i44/16480.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i44.16480