Pathology of alcoholic liver disease, can it be differentiated from nonalcoholic steatohepatitis?

Table 4 Differences in histologic features of nonalcoholic steatohepatitis and alcoholic liver disease

NAFLD (NASH)	ALD
Usually mild disease	Varying severity
Bridging necrosis rare	Bridging necrosis common
Poorly formed MH	Well formed MH
-/rare	Sclerosing hyaline necrosis
-/rare	Phlebosclerosis
-/rare	Canalicular cholestasis
Not described	Foamy degeneration
Nuclear vacuolation - more common	Nuclear vacuolation - less common
Presence of Iron/hemosiderin is less frequent	Presence of Iron/hemosiderin is more frequent
Ductular reaction is less frequent/prominent	Ductular reaction is more frequent/prominent
Fibrosis/cirrhosis - less common	Fibrosis/cirrhosis - more common

NAFLD: Non-alcoholic fatty liver disease; ALD: Alcoholic liver disease; NASH: Nonalcoholic steatohepatitis; MH: Mallory hyaline.