Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy

Figure 2 Insulin-like growth factor receptor-1 immunostaining of rectal cancer (× 200) and histopathological response to radiation (× 100) (a radioresistant sample). Strong cytoplasmic immunostaining of rectal cancer cells was seen on the pre-radiation biopsy specimen (left panel), correspondingly, poor histopathological response to radiation therapy was seen on the post-operative sample (right panel): most of the tumor remained, and little fibrosis was seen among the tumor cells.