Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy

Figure 1 Insulin-like growth factor receptor-1 immunostaining of rectal cancer (× 200) and histopathological response to radiation (× 100) (a radiosensitivitive sample). Negative cytoplasmic immunostaining of rectal cancer cells was seen on the pre-radiation biopsy specimen (left panel); correspondingly, good histopathological response to radiation therapy was seen on the post-operative sample (right panel): most of the entire lesion was replaced by fibrosis and necrosis, relic tumor glandular tubes and calcifications were seen.