Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation: A double-blind, active-comparator trial

Table 5 Adverse event

System/adverse event	Any adverse event
	Lubiprostone	Senna
	n = 31	n = 29
Number receiving at least one dose
Number of participants with any event	14 (45.2)	12 (41)
Gastrointestinal disorders
Nausea	3 (9.7)	5 (17.2)
Diarrhea	5 (16.1)	2 (6.9)
Abdominal pain	8 (25.8)	2 (6.9)
Abdominal cramping	6 (19.4)	6 (20.7)
Constipation	0	1 (3.4)
Nervous system disorders
Headache	0	1 (3.4)
Skin disorders rash	0	1 (3.4)
Musculoskeletal disorders
Patellar dislocation	1 (3.2)	0
Laboratory evaluations	0
Hematologic	0	1 (3.4)
Cardiovascular disorders
Cardiomyopathy		1 (3.4)
Total events	23	20

All adverse events in participants receiving at least one dose of study medication. Data are expressed as absolute numbers (percentage) or mean ± SD.