Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation: A double-blind, active-comparator trial

Table 4 Bowel movements and Bristol stool scale

Outcome measure	Intent to treat			Completers
	Lubiprostone	Senna	P value	Lubiprostone	Senna	P value
	n = 28	n = 28		n = 21	n = 22
Number of unsuccessful attempts for bowel movement
Baseline			0.17			0.29
0	10 (36)	11 (39)		5 (24)	7 (32)
1	4 (14)	8 (29)		3 (14)	7 (32)
2-3	10 (36)	5 (18)		9 (43)	4 (18)
4+	4 (14)	4 (14)		4 (19)	4 (18)
Day 7			0.31			0.60
0	15 (75)	17 (61)		10 (48)	14 (64)
1	6 (21)	7 (25)		6 (29)	5 (23)
2-3	7 (25)	4 (14)		5 (24)	3 (14)
4+	0 (0)	0 (0)		0 (0)	0 (0)
Change (improved)	9 (32)	12 (43)	0.42	12 (57)	13 (59)	0.92
Number of bowel movement
Baseline	0.96 ± 1.17	0.61 ± 0.83	0.19	0.95 ± 0.92	0.64 ± 0.90	0.26
Day 7	0.93 ± 0.90	0.93 ± 0.86	1.00	0.95 ± 0.92	0.91 ± 0.87	0.87
Change	-0.04 ± 1.50	0.32 ± 0.90	0.29	0.00 ± 1.22	0.27 ± 0.98	0.42
Consistency of bowel movement (Bristol stool scale)
Baseline			0.18			0.20
Type 1	4 (14)	0 (0)		4 (19)	0 (0)
Type 2	1 (4)	2 (17)		1 (5)	2 (9)
Type 3	3 (11)	4 (14)		2 (5)	3 (14)
Type 4	1 (4)	3 (11)		1 (5)	1 (5)
Type 5	2 (7)	0 (0)		2 (10)	0 (0)
Type 6	4 (14)	2 (7)		2 (10)	2 (9)
Type 7	1 (4)	0 (0)		1 (5)	0 (0)
NA	12 (43)	17 (59)		8 (38)	14 (64)
Day 7			0.32			0.22
Type 1	4 (14)	0 (0)		4 (19)	0 (0)
Type 2	1 (4)	4 (14)		1 (5)	4 (18)
Type 3	2 (7)	2 (7)		1 (5)	1 (5)
Type 4	6 (21)	10 (36)		5 (24)	8 (36)
Type 5	1 (4)	0 (0)		0 (0)	0 (0)
Type 6	2 (7)	2 (7)		2 (10)	1 (5)
Type 7	1 (4)	1 (4)		0 (0)	1 (5)
NA	11 (39)	9 (32)		8 (38)	7 (32)

Data are expressed as absolute numbers (percentage) or mean ± SD. NA: Not significant.