Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation: A double-blind, active-comparator trial

Table 1 Participant characteristics

Characteristics	Intent to treat			Completers
	Lubiprostone	Senna	P value	Lubiprostone	Senna	P value
	n = 28	n = 28		n = 21	n = 22
Age, yr	70.6 ± 12.1	72.5 ± 10.8	0.54	68.9 ± 12.6	69.6 ± 9.6	0.85
Weight, kg	88.5 ± 23.4	84.0 ± 16.7	0.42	93.4 ± 21.7	85.4 ± 17.0	0.20
Days postoperative, d	5.81 ± 2.72	7.71 ± 6.95	0.19	6.10 ± 2.90	6.50 ± 4.21	0.72
Sex, female	20 (74)	15 (54)	0.16	15 (71)	13 (59)	0.53
Race/ethnicity African American Hispanic Unknown White	5 (18) 1 (4) 2 (7) 20 (71)	7 (25) 0 (0) 3 (11) 18 (64)	0.76	6 (27) 0 (0) 0 (0) 16 (73)	4 (19) 1 (5) 1 (5) 15 (71)	0.72
Primary surgery Diagnosis Total knee or hip replacement Spinal surgery Hip/femur fracture Other	14 (50) 8 (14) 5 (9) 1 (2)	21 (75) 5 (18) 1 (4) 1 (4)	0.18	13 (62) 5 (24) 2 (10) 1 (5)	11 (50) 8 (32) 3 (18) 0 (0)	0.64

Data are expressed as absolute n (%) or mean ± SD.