Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

Table 1 Baseline characteristics and status of ulcer at 4 wk after endoscopic submucosal dissection

Parameter	2 wk(n = 27)	4 wk(n = 33)	P value
Clinical background
Age (yr)	73.3 ± 7.8	70.8 ± 9.3	NS2
Gender (male/female)	17/10	19/14	NS3
Helicobacter pylori infection (+/-/unknown)	18/8/1	25/6/2	NS3
Location (upper/middle/lower)	3/10/14	1/14/18	NS3
Size of ESD (mm2)	777.6 ± 437.8	1251.2 ± 918.6	0.0484
Serum albumin (g/dL)	4.1 ± 0.4	4.1 ± 0.4	NS2
Comorbidity
Diabetes (+/-)	3/24	6/27	NS3
Hyperlipidemia (+/-)	7/20	8/25	NS3
Hypertension (+/-)	8/19	11/22	NS3
Status of ulcer at 4 wk after ESD1
Stage of ulcer (active/healing/scar)	0/20/6	0/28/5	NS2
	Ulcer healing rate (%) (average, 95%CI)	96.1 (94.6-97.5)	94.8 (92.6-97.1)	NS3

¹One patient in 2 wk group who showed bleeding within 2 wk and received endoscopic treatment and proton pump inhibitor for 4 wk was excluded for these analysis;

²Paired t-test;

³χ² test;

⁴Mann-Whitney U test. ESD: Endoscopic submucosal dissection; NS: No significance.