Budd-Chiari syndrome: A single-center experience

Table 1 Clinical and laboratory characteristics n (%)

Clinical or laboratory feature	Entire cohort (n = 47)	TIPS with anticoagulation (n = 19)	Anticoagulation alone (n = 21)	P value
Age (yr) (Median, IQR)	42.4 (31.1, 52.1)	33.3 (29.7, 45.8)	46.9 (39.5, 57.3)	0.01
Gender
Male	16 (34.0)	6 (31.6)	7 (33.3)	0.91
Race/Ethnicity
African-American	11 (23.4)	5 (26.3)	3 (14.3)	0.69
White	32 (68.1)	12 (63.2)	16 (76.2)
Other	4 (8.5)	2 (10.5)	2 (9.5)
Hispanic/Latino	2 (4.3)	2 (10.5)	0 (0.0)	0.22
Comorbidities
Alcohol	2 (4.3)	0 (0.0)	1 (4.8)	1.00
Anemia	9 (19.1)	2 (10.5)	6 (28.6)	0.24
Cerebrovascular accident	1 (2.1)	1 (5.3)	0 (0.0)	0.47
Coronary artery disease	2 (4.3)	1 (5.3)	1 (4.8)	1.00
Chronic kidney disease	10 (21.3)	6 (31.6)	2 (9.5)	0.12
Chronic obstructive pulmonary disease	0 (0.0)	0 (0.0)	0 (0.0)
Congestive heart failure	1 (2.1)	0 (0.0)	1 (4.8)	1.00
Cirrhosis	26 (55.3)	13 (68.4)	8 (38.1)	0.05
Diabetes mellitus	8 (17.0)	1 (5.3)	4 (19.0)	0.34
Hypercholesterolemia	2 (4.3)	1 (5.3)	1 (4.8)	1.00
Peripheral vascular disease	0 (0.0)	0 (0.0)	0 (0.0)
Risk factors
Essential thrombocytosis	3 (6.4)	2 (10.5)	1 (4.8)	0.60
Factor V leiden mutation	4 (8.5)	1 (5.3)	2 (9.5)	1.00
Oral contraceptive use	2 (4.3)	2 (10.5)	0 (0.0)	0.23
Paroxysmal nocturnal hemoglobinuria	3 (6.5)	1 (5.3)	2 (9.5)	1.00
Protein C deficiency	2 (4.26)	1 (5.3)	1 (4.8)	1.00
Protein S deficiency	1 (2.1)	0 (0.0)	1 (4.8)	1.00
Polycythemia vera	14 (29.8)	9 (47.4)	4 (19.0)	0.09
Laboratory tests (Median, IQR) or (mean ± SD)
Albumin (g/dL)	2.9 ± 0.5	3.1 ± 0.6	2.7 ± 0.5	0.07
Alkaline phosphatase (U/L)	131 (98, 161)	131 (98, 177)	116 (96, 160)	0.69
Alanine aminotransferase (IU/L)	59 (36, 119)	76 (55, 190)	52 (39, 87)	0.11
Aspartate aminotransferase (IU/L)	67 (42, 113)	78 (54, 221)	66 (37, 96)	0.33
Bilirubin, total (mg/dL)	1.6 (1.2, 2.9)	1.7 (1.2, 4.0)	1.5 (0.9, 2.1)	0.42
Creatinine (mg/dL)	0.9 (0.6, 1.3)	0.8 (0.6, 1.2)	0.9 (0.6, 1.4)	0.80
Hemoglobin (mg/dL)	13.4 ± 2.7	14.5 ± 2.1	12.3 ± 2.9	0.02
International normalized ratio	1.7 (1.3, 2.2)	1.7 (1.4, 2.2)	1.5 (1.2, 2.6)	0.66
Platelet count (THO/μL)	217 (97, 329)	262 (181, 376)	173 (80, 238)	0.05
Disease severity (Diagnosis)
Child-Pugh (CP) score	9.2 ± 1.5	9.3 ± 1.3	8.9 ± 1.8	0.49
Model for end stage liver disease	17.1 ± 6.2	16.7 ± 4.9	18.9 ± 7.3	0.63
Rotterdam score
I	22	10	10	1.00
II	0	0	0
III	11	5	4
Follow-up time (d) (Median, IQR)	974 (393, 2697)	1101 (386, 2697)	834 (190, 1791)	0.36

TIPS: Transjugular intrahepatic portosystemic shunt; IQR: Interquartile range.