MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice

doi:10.3748/wjg.v20.i43.16227

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2014; 20(43): 16227-16235
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16227

Table 1 Primary pairs for real-time polymerase chain reaction of genes related to hepatic fatty acid metabolism

Gene name	Accession	Forward	Reverse
PPARα	Mm00440939
SREBP-1c	Mm00550338
SCD-1		GTTGGCTCCATCCATTGC	AACCATGGGAAGCCAAGTTT
FAS		AACCTCAGCAACACATCT	CGTTTACAAAGGGCATGCA
MTP	Mm00435015
CPT1		CCCTGGGCATGATTGCAA	AAGAGGACGCCACTCACGAT

PPARα: Peroxisome proliferator-activated receptor α; SREBP-1c: Sterol regulatory element binding transcription factor-1c; SCD-1: Stearoyl-CoA desaturase-1; FAS: Fatty acid synthase; MTP: Microsomal triglyceride transfer protein activity; CPT-1: Carnitine palmitoyltransferase-1.

Citation: Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M. MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice. World J Gastroenterol 2014; 20(43): 16227-16235
URL: https://www.wjgnet.com/1007-9327/full/v20/i43/16227.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i43.16227