Effect of liver regeneration on malignant hepatic tumors

doi:10.3748/wjg.v20.i43.16167

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2014; 20(43): 16167-16177
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16167

Table 2 Sum-up of signal pathways in hepatocellular carcinoma

Signaling pathways		Cell survival	Cell proliferation	Cell differentiation	Cell migration	Angiogenesis
Receptor tyrosine kinase signaling pathways	HGF/c-MET	√	√		√	√
	EGF(TGF-α)/EGFR	√	√
	IGF/IGFR	√	√		√
	VEGF/VEGFR					√
	PDGF/PDGFR					√
	TGF-β1/SMAD			√	√
Intercellular kinase signaling pathways	RAF/MEK/ERK	√	√	√		√
	PI3K/AKT/mTOR	√	√			√
	Wnt/β-catenin	√	√	√		√
	Hedgehog		√	√	√
	NK-κB, JAK/STAT3	√	√	√	√	√

HGF: Hepatocyte growth factor; EGF: Epidermal growth factor; TGF-α: Transforming growth factor alpha; IGF: Insulin-like growth factor; VEGF: Vascular endothelial growth factor; PDGF: Plate differentiation growth factor receptor; TGF-β: Transforming growth factor beta.

Citation: Shi JH, Line PD. Effect of liver regeneration on malignant hepatic tumors. World J Gastroenterol 2014; 20(43): 16167-16177
URL: https://www.wjgnet.com/1007-9327/full/v20/i43/16167.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i43.16167