Mitochondrial DNA alterations in the progression of gastric carcinomas: Unexplored issues and future research needs

Table 1 Clinicopathologic features of intestinal, gastric and diffuse types of distal gastric adenocarcinomas

	Intestinal-type adenocarcinoma	Gastric-type adenocarcinoma	Diffuse-type carcinoma
Age	Old age	Old age	Young age
Sex
(Male: Female)	2:1	Unknown data	1:1
Precancerous condition	Corpus-predominant	Corpus-predominant	Pangastritis
	gastritis with intestinal	Gastritis with pseudopyloric
	metaplasia	metaplasia
Precancerous lesion	Intestinal-type adenoma	Pyloric-gland adenoma	Tubular-neck dysplasia:
			signet-ring cell in situ
Gross feature	Exophytic lesion	Exophytic lesion	Ulcerative lesion and
			linitis plastic
Microscopy	Tubulopapillary glands	Tubulopapillary glands lined by columnar cells with clear mucinous cytoplasm	Discohesive cells or signet ring cells
	lined by columnar cells
	with eosinophilic cytoplasm
Immunohistochemistry	CD10 and MUC2	MUC5AC	Variable positivity for MUC1, MUC2, MUC5AC, MUC6
	immunoreactivity	immunoreactivity
Liver metastasis	Frequent	Rare	Rare
Peritoneal spread	Rare	Frequent	Frequent
Malignant potential	Low	High	High