Gut microbiota and metabolic syndrome

doi:10.3748/wjg.v20.i43.16079

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 21, 2014; 20(43): 16079-16094
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16079

Table 1 Studies conducted on animal models showing effects of probiotics containing Bifidobacterium strains on metabolic disorders

Studied animals	Probiotic	Dose	Duration of treatment (wk)	Effects	Ref.
C57BL/6J mice	Bifidobacterium breve B-3	10⁹ CFU	8	↓body weight, epididymal fat, serum cholesterol, glucose, insulin and HOMA index	[99]
C57BL/6J mice	Bifidobacterium breve B-3	10⁹ CFU	8	↑expression of FIAF, adiponectin	[99]
C57BL-6 mice	Bifidobacterium pseudocatenulatum CECT 7765		7	↓serum cholesterol, triglycerides, glucose, insulin resistance, leptin, IL-6, monocyte chemotactic protein-1, liver steatosis, adipose tissue	[100]
C57BL-6 mice	Bifidobacterium pseudocatenulatum CECT 7765		7	↑glucose tolerance	[100]
				Improvement of immune system functionality
HFD-fed rats	Bifidobacterium longum			Improvement of HFD induced metabolic disorders trough ↓endotoxin levels and intestinal inflammation, ↑expression of Reg I genes	[101]
HFD-rats, standard diets fed rats	Bifidobacterium adolescentis		12	↓visceral fat, liver steatosis	[102]
HFD-rats, standard diets fed rats	Bifidobacterium adolescentis		12	↑insulin sensitivity	[102]
Sprague-Dawley rats	B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207	10⁸-10⁹ CFU	7	↓body and fat weights, serum cholesterol, triglycerides, glucose, leptin, AST, ALT and lipase levels	[103]
Sprague-Dawley rats	Bifidobacteria L66-5, L75-4, M13-4 and FS31-12, originated from normal human intestines	10⁸ CFU	6	B. M13-4 strain ↑body weight	[104]
				B. L66-5 strain ↓body weight
				All strains ↓serum and liver triglycerides, serum and liver cholesterol

CFU: Colony-forming units; IL-6: Interleukin-6; HFD: High-fat diet; Reg I genes: Intestinal regenerating family genes; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; FIAF: Fasting-induced adipose factor; HFD: High-fat diet.

Citation: Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M, Colecchia A. Gut microbiota and metabolic syndrome. World J Gastroenterol 2014; 20(43): 16079-16094
URL: https://www.wjgnet.com/1007-9327/full/v20/i43/16079.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i43.16079