Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation

Table 2 Factors to differentiate severe acute exacerbation of chronic hepatitis B from acute hepatitis B

Parameters		AVH-B	HBV-R
IgM anti-HBc	> 600 Paul Ehrlich units/mL	Yes	Yes
		(7 s and 8 s forms)	(19 s form)
	> 1:1000 titer	Yes	No
HBV DNA	> 2.25 × 104/mL	No	Yes
	(121 000 copies/mL)
	Liver biopsy: evidence of chronic hepatitis such as lymphocytic portal inflammation with interface hepatitis, spotty lobular inflammation, portal expansion, periportal fibrous strands, bridging fibrosis, and/or cirrhosis			No	Yes
Basal core promoter mutation		No	Yes
Pre-core stop codon mutation		No	Yes

Jindal et al. Management of acute hepatitis B and reactivation of hepatitis B. Liver International 2013. HBV: Hepatitis B virus.