CYP2C19 polymorphism influences Helicobacter pylori eradication

doi:10.3748/wjg.v20.i43.16029

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2014; 20(43): 16029-16036
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16029

Table 1 Impact of cytochrome P450 2C19 genotypes on metabolism of proton pump inhibitors

	Genotype	Ratio (Asian)	Ratio (Caucasian)	Metabolism of PPIs
HomEM	wt/wt	30%-40%	70%	At highest rates
HetEM	wt/m1 or wt/m2	45%-55%	25%-27%	At moderate rates
PM	m1/m2	13%-23%	3%-5%	At lowest rates

HomEM: Homozygous extensive metabolizer; HetEM: Heterozygous extensive metabolizer; PM: Poor metabolizer; PPIs: Proton pump inhibitors; wt: Wild-type allele; m1/m2: Mutated alleles.

Citation: Kuo CH, Lu CY, Shih HY, Liu CJ, Wu MC, Hu HM, Hsu WH, Yu FJ, Wu DC, Kuo FC. CYP2C19 polymorphism influences Helicobacter pylori eradication. World J Gastroenterol 2014; 20(43): 16029-16036
URL: https://www.wjgnet.com/1007-9327/full/v20/i43/16029.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i43.16029