Delayed hypersensitivity reaction resulting in maculopapular-type eruption due to entecavir in the treatment of chronic hepatitis B

Figure 4 Cytokine release profile of peripheral blood mononuclear cells isolated from the patient during the cutaneous eruption associated with entecavir treatment. The level of secreted interleukin (IL)-4 was significantly elevated at 18 and 24 h after entecavir treatment. IL-4 is the representative cytokine of type 4b hypersensitivity.