Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model

Figure 4 Chitinase 3-like-1 inhibition may be one of the underlying mechanisms in the protective effect of caffeine. A: Caffeine suppresses CHI3L1 expression in both the CAC group and colitis group; B: Macroscopic overview of representative colonic samples from the CAC control group and the CAC + caffeine group; C: HE staining of colonic specimens from the colitis control group and caffeine-treated group (objective, 20 ×). CAC: Colitis-associated carcinoma; CHI3L1: Chitinase 3-like-1.