Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model

Figure 3 Chitinase 3-like-1 is up-regulated during the progression of carcinogenesis. A: Histological changes after AOM/DSS administration (HE staining, objective, 20 ×); B, C: CHI3L1 expression increased during the progression of colon carcinogenesis (B: Immunohistochemistry staining, objective, 40 ×). In Figure C, data represent mean ± SD. n = 3 at each time point. ^aP < 0.05 distal: day 56 vs day 0, 14, 28 and 42; ^bP < 0.01 distal: day 42 vs day 0, 14, 28; distal vs proximal. AOM: Azoxymethane; DSS: Dextran sulfate sodium; CAC: Colitis-associated carcinoma; CHI3L1: Chitinase 3-like-1.