Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs

Figure 5 In normal intact dog group with resection of the vagus nerve, interdigestive motor activity was observed after the intravenous administration of cisplatin (1. 2 mg/kg). A: Normal intact dog group with resection of the vagus nerve (NDRVN) (n = 4) was given cisplatin (1.2 mg/kg), and interdigestive motor activity was observed; B: In the NDRVN (n = 4), cisplatin (1.2 mg/kg) was given 1 h after granisetron (kytril) administration (0.05 mg/kg), and interdigestive motor activity was observed. i.v.: Intravenous administration.