Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs

Figure 4 Blocker study chart. In the ND, dexamethasone (1 mg/kg), phentolamine (regitin; 0.5 mg/kg), propranolol (inderal; 0.5 mg/kg), or granisetron (kytril; 0.05 mg/kg) was given as a single-bolus injection starting 20 min after the spontaneous phase III contractions of the jejunum 2 had terminated. Kytril (0.05 mg/kg) was also given as a single-bolus injection in the ND and NDRVN (n = 4). Cisplatin (1.2 mg/kg) was given 1 h after the administration of each inhibitor. In ND, atropine (0.05 mg/kg + 0.05 mg/kg per hour) was given as a single-bolus injection, followed by a 30-min continuous intravenous infusion starting 20 min after the spontaneous phase III contractions of the jejunum 2 had terminated. In the ND, metoclopramide (0.5 mg/kg + 0.5 mg/kg per hour) was given as a single-bolus injection, followed by a 5-h continuous intravenous infusion starting 20 min after the spontaneous phase III contractions of the jejunum 2 had terminated. Cisplatin (1.2 mg/kg) was given 1 h after the start of the administration of each inhibitor. ND: Normal intact dog group; NDRVN: Normal intact dog group with resection of the vagus nerve; i.v.: Intravenous administration.