Totally laparoscopic gastrectomy for gastric cancer: A systematic review and meta-analysis of outcomes compared with open surgery

Table 3 Pooled short-term outcomes

Outcomes	No. of studies	Sample size		Heterogeneity	Overall effect size	95%CI of overall effect	P value
		TLG	OG	(P value, I2)
Operation time (min)	14	721	811	< 0.001, 97%	WMD = 58.04	37.77-78.32	< 0.001
Blood loss (mL)	12	552	574	< 0.001, 87%	WMD = -167.57	-208.79-(-126.34)	< 0.001
Transfusion	3	268	233	0.11, 54%	RR = 0.49	0.21-1.11	0.09
Retrieved lymph nodes	13	683	789	0.04, 46%	WMD = -0.48	-2.21-1.26	0.59
Proximal margin (cm)	2	159	227	0.03, 80%	WMD = 0.00	-1.47-1.46	1.00
Distal margin (cm)	3	190	258	0.03, 70%	WMD = 0.94	-0.76-(2.64)	0.28
Analgesics given (d)	3	108	159	0.33, 11%	WMD = -1.79	-2.37-(-1.21)	< 0.001
Time to ambulation (d)	3	264	252	< 0.001, 93%	WMD = -0.91	-1.65-(-0.16)	0.02
Time to first flatus (d)	7	337	456	< 0.001, 98%	WMD = -1.97	-3.18-(-0.77)	0.001
Time to oral intake (d)	8	525	580	< 0.001, 96%	WMD = -2.39	-3.34-(-1.45)	< 0.001
Hospital stay (d)	13	683	789	< 0.001, 83%	WMD = -3.75	-4.88-(-2.63)	< 0.001
Overall complications	14	721	811	0.74, 0%	RR = 0.71	0.58-0.86	< 0.001
Surgical complications	12	635	690	0.76, 0%	RR = 0.75	0.57-0.98	0.03
Medical complications	11	615	670	0.97, 5%	RR = 0.57	0.38-0.86	0.008
Mortality	7	412	434	0.96, 0%	RR = 0.65	0.24-1.76	0.40

WMD: Weighted mean difference; RR: Risk ratio; TLG: Totally laparoscopic gastrectomy; OG: Open gastrectomy.