Totally laparoscopic gastrectomy for gastric cancer: A systematic review and meta-analysis of outcomes compared with open surgery

Table 1 Summary of studies included in the meta-analysis

Ref.	Region	Study design	Year	Study period	Sample size		Level of lymphad-enectomy	Surgical extension	Reconstruction	Conversion	Mortality		Matched factors1	Quality scores
					TLG	OG					TLG	OG
Huscher et al[25]	Italy	RCT	2005	1992-1996	30	29	D1, D2	D	B-II, R-Y	NR	3.3%	6.7%	-	32
Pugliese et al[26]	Italy	OCS (R)	2007	2000-2005	48	99	D2	S, T	R-Y	2.1%	2.1%	3.0%	-	7
Song et al[27]	South Korea	OCS (P)	2008	2005-2006	20	20	D1 + β, D2	D	B-I, R-Y	0	0	0	-	8
Lee et al[28]	Taiwan	OCS (P)	2008	1998-2005	34	34	D2	S	B-II	2.9%	0	0	1245	9
Topal et al[29]	Belgium	OCS (R)	2008	2003-2006	38	22	D2	T	R-Y	NR	2.6%	4.5%	-	8
Strong et al[30]	United States	OCS (P)	2009	2005-2008	30	30	D2	S	B-II, R-Y	NR	0	0	1245	9
Wong et al[31]	Hong Kong	OCS (R)	2009	2001-2006	18	41	D1 + α/β, D2	D	B-II, R-Y	5.0%	0	2.4%	-	7
Chouillard et al[32]	France	OCS (P)	2010	2001-2007	51	79	D2	D, T	B-II, R-Y	6.0%	0	2.5%	-	9
Scatizzi et al[33]	Italy	OCS (P)	2011	2006-2009	30	30	D2	D	R-Y	6.7%	0	0	12345	9
Moisan et al[34]	Chile	OCS (R)	2012	2005-2010	31	31	D1 + α/β, D2	S, T	B-II, R-Y	3.2%	0	0	1245	9
Cianchi et al[35]	Italy	OCS (P)	2012	2008-2012	41	41	D1 + α/β, D2	S, T	B-II, R-Y	0	2.4%	4.9%	1245	8
Siani et al[36]	Italy	OCS (R)	2012	2003-2009	25	25	D1 + α/β, D2	T	R-Y	0	0	0	145	9
Shinohara et al[37]	Japan	OCS (P)	2013	1998-2008	186	123	D2	D, P, T	B-I, R-Y	2.2%	1.1%	0	12345	9
Kim et al[38]	South Korea	OCS (P)	2013	2011	139	207	D2	T	R-Y	0	0	0	-	7

¹Jadad scores;

²Factors matched between groups: 1: Age; 2: Sex; 3: Body mass index; 4: Stage; 5: Type of gastrectomy. RCT: Randomized controlled trial; OCS: Observational clinical study; P: Prospectively collected data; R: Retrospectively collected data; TLG: Totally laparoscopic gastrectomy; OG: Open gastrectomy; D: Distal gastrectomy; P: Proximal gastrectomy; T: Total gastrectomy; S: Subtotal gastrectomy; B-I: Billroth-I; B-II: Billroth-II; R-Y: Roux-en-Y; NR: Not reported.