Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation

doi:10.3748/wjg.v20.i42.15820

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2014; 20(42): 15820-15829
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15820

Table 3 Multivariate analysis of overall survival

Variable	Main cohort		External reference cohort
Variable	HR (95%CI)	P value	HR (95%CI)	P value
Chemotherapy¹	1.09 (0.55-2.16)	0.810
Type of response after CRT
ypT0N0	NE		0.61 (0.19-2.02)	0.420
ypT1-2N0	0.30 (0.11-0.78)	0.014	0.32 (0.13-0.83)	0.019
ypT3-4/N1-2	Reference		Reference
CEA	1.00 (0.97-1.03)	0.780
Presurgical clinical stage
T2-3N0			Reference
T4 and/or N1			1.89 (0.95-3.76)	0.069

¹This factor was not evaluated in the external reference cohort because all patients were scheduled to receive chemotherapy. CEA: Carcinoembryonic antigen; CRT: Chemoradiotherapy; NE: Not estimable (no deaths).

Citation: García-Albéniz X, Gallego R, Hofheinz RD, Fernández-Esparrach G, Ayuso-Colella JR, Bombí JA, Conill C, Cuatrecasas M, Delgado S, Ginés A, Miquel R, Pagés M, Pineda E, Pereira V, Sosa A, Reig O, Victoria I, Feliz L, María de Lacy A, Castells A, Burkholder I, Hochhaus A, Maurel J. Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation. World J Gastroenterol 2014; 20(42): 15820-15829
URL: https://www.wjgnet.com/1007-9327/full/v20/i42/15820.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i42.15820