Can composite performance measures predict survival of patients with colorectal cancer?

Table 2 Characteristics of patients undergoing colectomy for colorectal adenocarcinoma n (%)

Parameter	Cohort 1	Cohort 2	Cohort 3
	(n = 1164)	(n = 790)	(n = 1318)
Age (yr)	66.8 ± 13.1	65.4 ± 13.6	64.3 ± 12.8
Sex (M/F)	656 (56.4)/	431 (54.6)/	781 (59.3)/
	508 (43.6)	359 (45.4)	537 (40.7)
Location
Rectum	-	-	1318 (100)
Rectosigmoid junction	124 (10.7)	88 (11.1)	-
Sigmoid	440 (37.8)	313 (39.6)	-
Descending	124 (10.7)	72 (9.1)	-
Splenic flexure	35 (3.0)	17 (2.2)	-
Transverse	107 (9.2)	70 (8.9)	-
Hepatic flexure	47 (4.0)	38 (4.8)	-
Ascending	173 (14.9)	118 (14.9)	-
Cecum and appendix	77 (6.6)	44 (5.6)	-
Overlapping	12 (1.0)	7 (0.9)	-
Unspecified	25 (2.1)	23 (2.9)	-
Comorbidity
CCI (0 or 1)	63 (5.4)	26 (3.3)	73 (5.5)
CCI (2)	659 (56.6)	103 (25.7)	531 (40.3)
(> 3)	442 (37.9)	661 (71.0)	714 (54.2)
Grade
Well differentiated	102 (8.8)	46 (5.8)	101 (7.7)
Moderately differentiated	937 (80.5)	640 (81.0)	1072 (81.3)
Poorly differentiated	61 (5.2)	87 (11.0)	89 (6.8)
Un-differentiated	1 (0.1)	-	1 (0.1)
Unspecified	63 (5.4)	17 (2.2)	55 (4.2)
Staging (p)
Stage I	295 (25.3)	-	311 (23.6)
Stage II	869 (74.7)	-	459 (34.8)
Stage III	-	790 (100.0)	548 (41.6)
pT1	133 (11.4)	15 (1.9)	107 (8.1)
pT2	164 (14.1)	37 (4.7)	287 (21.8)
pT3	694 (59.6)	574 (72.7)	719 (54.6)
pT4	162 (13.9)	158 (20.0)	198 (15.0)
Unspecified	11 (0.9)	6 (0.8)	7 (0.5)
pN0	1164 (100)	-	767 (58.2)
pN1	-	505 (63.9)	299 (22.7)
pN2	-	280 (35.4)	246 (18.7)
Unspecified	-	5 (0.6)	6 (0.5)
Lymph node examination	17.7 ± 12.6	19.3 ± 13.9	15.4 ± 10.0
Chemotherapy (yes)	306 (26.3)	600 (75.9)	654 (49.6)
Radiotherapy (yes)	23 (2.0)	32 (4.1)	308 (23.4)
Follow-up months (range)	57.1 ± 20.1	51.3 ± 23.2	54.7 ± 21.3
	(0-84.0)	(0.1-84.0)	(0-83.8)
Five-year survival rate	87.1	73	88.7

Pathological staging and T and N classifications as defined by the American Joint Committee on Cancer, 6^th edition. CCI: Charlson comorbidity index; M/F: Male/Female; p: Pathological.