Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model

Table 2 Body weight, organ weights, serum biochemistry parameters and oxidative stress parameters

Groups	Normal	Alcohol	Alcohol with CGX treatment		CGX 200
			100	200
Body mass (g)	347.3 ± 15.6	325.4 ± 20.4a	327.8 ± 24.6	329.5 ± 16.0	332.3 ± 16.5
Liver mass (g)	10.2 ± 0.7	10.1 ± 1.5	9.3 ± 1.2	9.6 ± 0.7	9.2 ± 0.6
Spleen mass (g)	0.8 ± 0.1	0.8 ± 0.1	0.7 ± 0.1	0.8 ± 0.1	0.8 ± 0.1
Liver mass (%)	2.9 ± 0.1	3.1 ± 0.5	2.8 ± 0.3	2.9 ± 0.1	2.8 ± 0.1
Spleen mass (%)	0.2 ± 0.0	0.2 ± 0.0	0.2 ± 0.0	0.2 ± 0.0	0.2 ± 0.0
AST (IU/L)	119.7 ± 18.1	226.3 ± 120.2a	125.1 ± 18.1c	105.3 ± 9.8c	106.7 ± 5.2
ALT (IU/L)	45.8 ± 2.5	91.0 ± 39.5a	70.3 ± 10.9c	54.2 ± 6.5c	45.7 ± 7.7
ALP (IU/L)	203.0 ± 29.7	269.9 ± 111.2	190.7 ± 33.4	174.9 ± 17.3	162.8 ± 20.0a
LDH (IU/L)	1406.4 ± 68.3	1646.1 ± 224.3a	1338.0 ± 444.6	1009.6 ± 164.1d	925.2 ± 115.2a

Rats were orally administered with alcohol (10 mL of 30% ethanol/kg) with/without CGX (100 or 200 mg/kg) for 4 wk. Body weight were recorded twice weekly during experiment. At the end of the experiment, whole blood was collected and liver and spleen were removed. Data were expressed as mean ± SD (n = 6-9);

^aP < 0.05 vs normal group;

^cP < 0.05 vs alcohol group;

^dP < 0.01 vs alcohol group. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; LDH: Lactic dehydrogenase.