Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects

Table 5 New diagnostic criteria for the hepatorenal syndrome from the International Ascites Club (2013)[192]

Cirrhosis with ascites

Serum creatinine > 133 μmol/L (1.5 mg/dL)

No improvement of serum creatinine (decrease to a level of < 133 μmol/L) after at least 2 d with diuretic withdrawal and volume expansion with albumin. 1 g/kg of body weight per day up to a maximum of 100 g/d

Absence of shock

No current treatment with nephrotoxic drugs

Absence of parenchymal kidney disease as indicated by proteinuria > 500 mg/d, or microhaematuria, (> 50 red blood cells per high power field) and /or a normal renal ultrasonography