Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis

Figure 2 Effect of hydroxynaphthoquinone mixture on colon length (A), colonic myeloperoxidase activity (B) and serum tumor necrosis factor-α level (C) in dextran sulfate sodium-induced mouse ulcerative colitis. Colitis was induced by administration with 3.5% dextran sulfate sodium (DSS) for 6 d. Hydroxynaphthoquinone mixture (HM) (3.5, 7, 14 mg/kg respectively) or mesalazine 200 mg/kg was administered daily for 7 d. Myeloperoxidase (MPO) activity was determined using an MPO detection kit. Tumor necrosis factor-α (TNF-α) level was determined by enzyme-linked immunosorbent assay. Data are presented as mean ± SD of eight to ten mice. ^bP < 0.01 vs control; ^cP < 0.05 vs DSS alone.