Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis

Figure 1 Effect of hydroxynaphthoquinone mixture on the clinical signs and body weight change of mice. A: Body weight change; B: Disease activity index. Colitis was induced by administration with 3.5% dextran sulfate sodium (DSS) for 6 d. Hydroxynaphthoquinone mixture (HM) (3.5, 7, 14 mg/kg) or mesalazine 200 mg/kg was administered daily for 7 d. Disease progression was monitored daily by observation of clinical signs and body weight change. Data are presented as mean ± SD of eight to ten mice. ^aP < 0.05 vs control, ^bP < 0.01 vs DSS alone.