N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury

Figure 5 Reactive oxygen species or endoplasmic reticulum stress-induced hepatocyte death is inhibited by N-acetylcysteine treatment. A: Western blot-assisted analysis of BCL-2, BCL-xl and β-actin; B: released lactate dehydrogenase level of primary hepatocytes after H₂O₂ (200 μmol) or TG (1 µmol) treatment; mean ± SD, n = 4/group, ^bP < 0.01 vs Ctrl group; ^dP < 0.01 vs H₂O₂ group; ^fP < 0.01 vs Ctrl group; ^hP < 0.01 vs TG group; C: schematic illustration of NAC works in IR-stressed liver. NAC: N-acetylcysteine; IR: Ischemia-reperfusion; Ctrl: Control; ROS: Reactive oxygen species.