N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury

Figure 2 N-acetylcysteine treatment reduces hepatocellular apoptosis in liver after ischemia-reperfusion. A: Liver apoptosis by transferase dUTP nick-end labeling staining: A1: Sham group; A2: IR group; A3: NAC sham group; A4: NAC + IR group; B: apoptotic cells were quantified in six high-power fields (× 400), and expressed as percentages of apoptotic cells among total cells; mean ± SD, n = 3-5/group, ^bP < 0.01 vs sham group; ^dP < 0.01 vs IR group; C: caspase-3 activity; mean ± SD, n = 3-5/group, ^bP < 0.01 vs sham group; ^dP < 0.001 vs IR group. NAC: N-acetylcysteine; IR: Ischemia-reperfusion.