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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 7, 2014; 20(41): 15087-15097
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15087
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15087
Figure 2 Hypoxia-inducible factors regulate hepatic lipid metabolism.
HIF-2 promotes lipid accumulation mainly by preventing mitochondrial β-oxidation and promoting lipid droplet formation. In contrast, HIF-1 suppresses lipid accumulation by inhibiting de novo lipogenesis. HIF-1 also promotes lipid storage and lipid export. HIF: Hypoxia-inducible factor; FA: Fatty acids; TG: Triglycerides.
- Citation: Suzuki T, Shinjo S, Arai T, Kanai M, Goda N. Hypoxia and fatty liver. World J Gastroenterol 2014; 20(41): 15087-15097
- URL: https://www.wjgnet.com/1007-9327/full/v20/i41/15087.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i41.15087