Effect of spleen operation on antiviral treatment in hepatitis C virus-related cirrhotic patients

Table 4 Comparison of antiviral therapy between patients with and without spleen operation based on controlled studies

Ref.	SVR		SVR for GT-1		SVR for GT-2/3		IFN dosage reduction		Discontinuation		HCC
	SO	Non-SO	SO	Non-SO	SO	Non-SO	SO	Non-SO	SO	Non-SO	SO	Non-SO
Aizawa et al[17], 2013	6/30	12/60	3/25	8/50	3/5	4/10	NA	NA	NA	NA	NA	NA
Morihara et al[24], 2009	4/111	7/32	0/7	1/18	4/4	6/14	0/16	8/32	3/16	8/32	4/16	16/32
Motomura et al[25], 2012	16/37	38/90	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Miyake et al[29], 2008	6/10	3/10	2/6	0/6	4/4	3/4	3/10	5/10	2/10	1/10	NA	NA
Tahara et al[30], 2011	9/30	5/23	1/15	1/14	8/15	4/9	16/30	10/23	4/30	2/23	4/30	NA
Takahara et al[31], 2011	3/11	6/13	2/10	4/8	1/1	2/5	5/11	11/13	1/11	1/13	NA	NA
Summary	44/129	71/228	8/63	14/96	20/29	19/42	24/67	34/78	10/67	12/78	8/46	16/32

¹Five patients were receiving treatment. SO: Spleen operation; Non-SO: No spleen operation; SVR: Sustained virological response; GT: Genotype; IFN: Interferon; HCC: Hepatocellular carcinoma; NA: Not available.